Popular Mechanics is like Popular Science right? Extremely bullish on new technologies to the degree of taking one study and turning it into a breathless article about how we're 1 year away from flying cars?
Sorry for the cynicism, but I grew up subscribing to Popular Science and I gained a very jaundiced view of this kind of science/technology popularizing
Confused a bit by the article: it mentions human trials began in september 2024, but also that the trials that might prove it working are yet to start?
I think it's just poorly written. If you go to the source[1] the trial period was planned from September 2024 to August 2025, and the submission says people are "undergoing" a trial. Perhaps it got delayed, or, more likely IMHO, the trial period is over and they're studying the data so haven't made reached a conclusion yet.
Aren't the shape/size/placement/etc. of human teeth fairly unique across different individuals? At least unique enough to use dental records to identify bodies.
I don't see if mentioned in TFA, but if new human teeth can be grown is it expected that the new ones will just grow in "correctly" to fit a person's mouth?
> At least unique enough to use dental records to identify bodies.
Yes but in comparative dental analysis they use ante-mortem dental records to compare with post-mortem remains. It's not like DNA where you can record it once and then use that to match samples decades later in a database. In order to have a high confidence in a match, recent x-rays and records of dental work like fillings, crowns, etc. work best.
And no it is not expected. It's one of the primary challenges with bringing these kinds of drugs to market, as hyperdontia is already relatively common among humans (I had an incisor growing at the roof of my mouth an inch behind my row of teeth). Most successful applications of these tooth regrowth drugs tend to place them near the root of missing teeth hoping that the cellular growth signaling mechanisms are still working.
Fun fact - all of your adult teeth were already there from the start, hiding under(inside?) the gums. We don't "grow" new teeth when the baby teeth fall out - the adult teeth were always there under them.
I am hoping for advancements in cartilage growth. I underwent microfracture surgery in my knee and will eventually need a replacement unless we make progress in this field. I would prefer to avoid knee replacement if possible because I enjoy being active. I am hopeful we’re getting close.
Anecdotal, but I was going in for carpal tunnel work and ran into an older gentleman, probably early 70s, that had just gone through a knee replacement a week earlier. He was walking around on it and said he wasn't really in any pain.
Well, I'm personally hoping stem cells pull through for corneal tissue regrowth. I've got significant scarring in one eye. I'd rather not get a donor (cadaver) cornea sewn on if it's avoidable but we'll see.
I'm sure you're correct. That said, I saw a friend who went bald at 28 get all of his hair back from Minoxidil + finasteride. Maybe his folicles weren't closed/gone but he was bald and a year later, was not.
Apparently there's also now-a-days, Micro-needling, Stem Cell Therapy, Platelet-Rich Plasma, and others. No idea how effective they actually are
I've been taking vitamin k2 mk4 at 45mg a day for over a year now. My teeth feel gr8. Now I need to get some of this stuff to have super human chompers.
This guy's been downvoted badly but he's right - vitamin k2 make your teeth into "superteeth".
I started K2 about 10 years ago. Next dental checkup (about a year too late) the dental tech said my teeth appeared recently-cleaned. This has continued since then. No cavities, little cleaning required other than regular brushing, flossing and taking k2.
Popular Mechanics is like Popular Science right? Extremely bullish on new technologies to the degree of taking one study and turning it into a breathless article about how we're 1 year away from flying cars?
Sorry for the cynicism, but I grew up subscribing to Popular Science and I gained a very jaundiced view of this kind of science/technology popularizing
Confused a bit by the article: it mentions human trials began in september 2024, but also that the trials that might prove it working are yet to start?
I think it's just poorly written. If you go to the source[1] the trial period was planned from September 2024 to August 2025, and the submission says people are "undergoing" a trial. Perhaps it got delayed, or, more likely IMHO, the trial period is over and they're studying the data so haven't made reached a conclusion yet.
[1]: https://www.kitano-hp.or.jp/info/20240503
It’s a phase 1 clinical trial designed only to assess safety and determine the appropriate dosage. Future trials will focus on efficacy.
Don't need teeth yet (lol), but curious if anyone is aware of a similar/new ways to restore the enamel?
https://www.bbc.com/news/articles/cn09kwrg57do
Mix hair in your toothpaste
https://www.bbc.com/news/articles/c9qy0w27213o
Aren't the shape/size/placement/etc. of human teeth fairly unique across different individuals? At least unique enough to use dental records to identify bodies.
I don't see if mentioned in TFA, but if new human teeth can be grown is it expected that the new ones will just grow in "correctly" to fit a person's mouth?
> At least unique enough to use dental records to identify bodies.
Yes but in comparative dental analysis they use ante-mortem dental records to compare with post-mortem remains. It's not like DNA where you can record it once and then use that to match samples decades later in a database. In order to have a high confidence in a match, recent x-rays and records of dental work like fillings, crowns, etc. work best.
And no it is not expected. It's one of the primary challenges with bringing these kinds of drugs to market, as hyperdontia is already relatively common among humans (I had an incisor growing at the roof of my mouth an inch behind my row of teeth). Most successful applications of these tooth regrowth drugs tend to place them near the root of missing teeth hoping that the cellular growth signaling mechanisms are still working.
Teeth wear quite a bit too, I wonder will new ones have to be pared down to fit.
This is like fusion energy. It's been 4 years away since I've been a child.
I personally regrew my teeth since I was a child. Granted, once.
Fun fact - all of your adult teeth were already there from the start, hiding under(inside?) the gums. We don't "grow" new teeth when the baby teeth fall out - the adult teeth were always there under them.
Did they get bigger as you were "Growing up"? Then we grow teeth, you're just being pedantic about whether they're brand new or not.
Let’s hope teeth won’t grow in places they shouldn’t.
a haircut made of teeth though, hmm
We all shoult fear the vagina dentata.
Scientists regrowing everything except hair. Fuck my life.
I am hoping for advancements in cartilage growth. I underwent microfracture surgery in my knee and will eventually need a replacement unless we make progress in this field. I would prefer to avoid knee replacement if possible because I enjoy being active. I am hopeful we’re getting close.
Anecdotal, but I was going in for carpal tunnel work and ran into an older gentleman, probably early 70s, that had just gone through a knee replacement a week earlier. He was walking around on it and said he wasn't really in any pain.
I was amazed.
YMMV.
And limbs.
I would say every tissue: no bones, no organs, eyes, ears, nerves, skin.
Like what can they grow?
Well, I'm personally hoping stem cells pull through for corneal tissue regrowth. I've got significant scarring in one eye. I'd rather not get a donor (cadaver) cornea sewn on if it's avoidable but we'll see.
I think they're making progress.
The liver is an exception here - you can grow back a lot of it.
finasteride + minoxidil
Just keep your mental health in mind - there's growing concern that the link between finasteride and depression has been underestimated [0].
[0] https://www.psychiatrist.com/jcp/analytical-review-depressio...
Once the follicle is closed/gone, it’s gone.
Minoxidil won’t help grow hair on a patch of bold skin. After that only hair transplantation
I'm sure you're correct. That said, I saw a friend who went bald at 28 get all of his hair back from Minoxidil + finasteride. Maybe his folicles weren't closed/gone but he was bald and a year later, was not.
Apparently there's also now-a-days, Micro-needling, Stem Cell Therapy, Platelet-Rich Plasma, and others. No idea how effective they actually are
Well he even had alopecia or he got hair transplant. There is sadly no other option.
If you don't have sides that is
Growth rate and how you don’t mess it up before it matures are problems
I've been taking vitamin k2 mk4 at 45mg a day for over a year now. My teeth feel gr8. Now I need to get some of this stuff to have super human chompers.
Why mk4 over mk7?
This guy's been downvoted badly but he's right - vitamin k2 make your teeth into "superteeth".
I started K2 about 10 years ago. Next dental checkup (about a year too late) the dental tech said my teeth appeared recently-cleaned. This has continued since then. No cavities, little cleaning required other than regular brushing, flossing and taking k2.
What changes in your subjective sensation of your teeth with K2?