”After adjusting for potential confounders and pooling results across cohorts, higher caffeinated coffee intake was significantly associated with lower dementia risk (141 vs 330 cases per 100 000 person-years comparing the fourth [highest] quartile of consumption with the first [lowest] quartile; hazard ratio, 0.82 [95% CI, 0.76 to 0.89]) and lower prevalence of subjective cognitive decline (7.8% vs 9.5%, respectively; prevalence ratio, 0.85 [95% CI, 0.78 to 0.93]).”
So about 18% relative reduction. But if your risks are already low (e.g. active and healthy diet) the relative reduction is less impactful (e.g. 4% to 3.28%).
Coffee, like other beans, is loaded to the hilt with antioxidants, particularly once it’s hyper-concentrated, and the roasting and brewing process eliminates all the mechanisms beans normally use to avoid animals wanting to eat them.
Isn't this all about brain hypoperfusion coming from some sort of dysautonomia and/or mitochondrial dysfunction and worse blood vessels as we age? We know that medication that helps blood flow and endothelium improves brain long-term, like sildenafil.
Is that right? Isn't it more related to the fact that people in education/etc. actually drink more coffee for culture reasons but also use their brain more? could that be the actual reason? Because I don't see how all the coffee zombies in my workplace would last longer long term when they're already useless and aggressive today (until they had their coffee)
This was a follow-on to a study of nurses showing coffee drinkers have lower all cause mortality.
Caffeine has been shown to exert effects via adenosine receptor antagonism and influence on cAMP & AMPK pathways. These same pathways are implicated in a lot of issues with aging. Caffeine also has some anti-inflammatory properties and Coffee beans are a strong anti-oxidant though I don't really think that matters much.
> Caffeine has been shown to exert effects via adenosine receptor antagonism and influence on cAMP & AMPK pathways. These same pathways are implicated in a lot of issues with aging.
That is like saying biological pathways are implicated in aging (because you said "pathways").
In any case, adenosine receptor antagonism has a pretty weak link if any to aging.
Additionally, we say that about virtually everything that is herbal, that it has anti-inflammatory properties. You are right, it does not matter at all.
Actual study: https://jamanetwork.com/journals/jama/article-abstract/28447...
”After adjusting for potential confounders and pooling results across cohorts, higher caffeinated coffee intake was significantly associated with lower dementia risk (141 vs 330 cases per 100 000 person-years comparing the fourth [highest] quartile of consumption with the first [lowest] quartile; hazard ratio, 0.82 [95% CI, 0.76 to 0.89]) and lower prevalence of subjective cognitive decline (7.8% vs 9.5%, respectively; prevalence ratio, 0.85 [95% CI, 0.78 to 0.93]).”
So about 18% relative reduction. But if your risks are already low (e.g. active and healthy diet) the relative reduction is less impactful (e.g. 4% to 3.28%).
> the relative reduction is less impactful (e.g. 4% to 3.28%
That's also an 18% reduction
Coffee, like other beans, is loaded to the hilt with antioxidants, particularly once it’s hyper-concentrated, and the roasting and brewing process eliminates all the mechanisms beans normally use to avoid animals wanting to eat them.
Then again if you have dementia, you are highly likely to lesve the office environment and any study, thus reversing causality.
Does not apply to the White House
Isn't this all about brain hypoperfusion coming from some sort of dysautonomia and/or mitochondrial dysfunction and worse blood vessels as we age? We know that medication that helps blood flow and endothelium improves brain long-term, like sildenafil.
Is that right? Isn't it more related to the fact that people in education/etc. actually drink more coffee for culture reasons but also use their brain more? could that be the actual reason? Because I don't see how all the coffee zombies in my workplace would last longer long term when they're already useless and aggressive today (until they had their coffee)
This was a follow-on to a study of nurses showing coffee drinkers have lower all cause mortality.
Caffeine has been shown to exert effects via adenosine receptor antagonism and influence on cAMP & AMPK pathways. These same pathways are implicated in a lot of issues with aging. Caffeine also has some anti-inflammatory properties and Coffee beans are a strong anti-oxidant though I don't really think that matters much.
> Caffeine has been shown to exert effects via adenosine receptor antagonism and influence on cAMP & AMPK pathways. These same pathways are implicated in a lot of issues with aging.
That is like saying biological pathways are implicated in aging (because you said "pathways").
In any case, adenosine receptor antagonism has a pretty weak link if any to aging.
Additionally, we say that about virtually everything that is herbal, that it has anti-inflammatory properties. You are right, it does not matter at all.
The studies compared people from the same occupation, so no, that is not likely the reason
But that can still not account for cultural/work ethic differences.
Exactly. Just another “study” finding a correlation without causation.
Original source: https://jamanetwork.com/journals/jama/article-abstract/28447...
Does decaf have the same effects ?
No, only caffeinated
> decaffeinated coffee intake was not associated with lower dementia risk or better cognitive performance
You'd be missing out on the anti-inflammatory properties of the caffeine, so maybe it might have some effect?