As slow as it may be to adopt, it's a welcome change to how people should do research. Why induce suffering on an animal when the potential for failure and or miscalculation is so high? It seems from the article a model/chip can be more insightful on how something will affect humans.
2) When testing in animals, first ensure that there is reasonable confidence the risk and severity of harm from the testing will be minimal. Only begin initial in vivo testing after this has first been achieved.
3) For test animals that are or aren't harmed, allow them to live happy, (relatively) normal, natural lives. Don't end their life early unnecessarily, with exceptions for humane euthanasia if the testing has unexpectedly caused significant, persistent suffering. Treat them as a pet owner would treat their beloved pet rat.
Some may consider it extreme, but, in my view, in an ideal world, people would treat testing in animals almost like testing in humans. The researcher should first ask "would I feel comfortable testing this in a voluntary human test subject?" Non-human animals would still be the first line of testing, since harm/death in a rat/mouse/chimpanzee is less morally bad than in a human, but I think this should be the mindset.
Ah lest we forget about Jevons Paradox. With the ability to discover a nearly infinite number of potential breakthroughs, we are going to need more animal testing than ever!
the FDA wanted data from organs-on-a-chip or some comparable alternative.
This is the main takeaway from the article imho and great news! ~15 years ago those systems were were not very interesting for pharma companies (bayer used to have a campus a few s-bahn stops away) due to regulators requiring animal tests over those systems.
Funny animal research story: University had an animal research committee to which anyone wanting to "use" an animal on university property had to submit proposals. Theatre department wants to "borrow" a lamb from the school's agricultural department research herd. Female character was to hold a live lamb during several stage scenes. Three shows a week for about a month. Everyone laughed. Then came the objection:
As the lamb would be exposed to uncontrolled people/pathogens it could not be used for further scientific studies nor returned to the herd. There was doubt it could even be sold for food. So, absent anyone taking it home as a pet, its appearance on stage was more of a death sentence than any scientific study!
As slow as it may be to adopt, it's a welcome change to how people should do research. Why induce suffering on an animal when the potential for failure and or miscalculation is so high? It seems from the article a model/chip can be more insightful on how something will affect humans.
It should be a tiered system, IMO.
1) Where possible, don't test in animals.
2) When testing in animals, first ensure that there is reasonable confidence the risk and severity of harm from the testing will be minimal. Only begin initial in vivo testing after this has first been achieved.
3) For test animals that are or aren't harmed, allow them to live happy, (relatively) normal, natural lives. Don't end their life early unnecessarily, with exceptions for humane euthanasia if the testing has unexpectedly caused significant, persistent suffering. Treat them as a pet owner would treat their beloved pet rat.
Some may consider it extreme, but, in my view, in an ideal world, people would treat testing in animals almost like testing in humans. The researcher should first ask "would I feel comfortable testing this in a voluntary human test subject?" Non-human animals would still be the first line of testing, since harm/death in a rat/mouse/chimpanzee is less morally bad than in a human, but I think this should be the mindset.
I agree. If it’s a question of just cost - (animals being cheaper to just test on quickly and faster) animal testing shouldn’t be allowed.
Ah lest we forget about Jevons Paradox. With the ability to discover a nearly infinite number of potential breakthroughs, we are going to need more animal testing than ever!
(Sarcasm but also some potential truth)
Nice to see TissUse getting a shout out :)
This is the main takeaway from the article imho and great news! ~15 years ago those systems were were not very interesting for pharma companies (bayer used to have a campus a few s-bahn stops away) due to regulators requiring animal tests over those systems.“It’s people man! We’re the ones who are miserable, so why shouldn’t we get to try it all first?!”
- Sealab 2021
This was already figured out and built out years ago https://www.darpa.mil/research/programs/microphysiological-s...
Funny animal research story: University had an animal research committee to which anyone wanting to "use" an animal on university property had to submit proposals. Theatre department wants to "borrow" a lamb from the school's agricultural department research herd. Female character was to hold a live lamb during several stage scenes. Three shows a week for about a month. Everyone laughed. Then came the objection:
As the lamb would be exposed to uncontrolled people/pathogens it could not be used for further scientific studies nor returned to the herd. There was doubt it could even be sold for food. So, absent anyone taking it home as a pet, its appearance on stage was more of a death sentence than any scientific study!
They opted for a doll.