Humans have the same protein. Knock out studies in mice have historically been very informative about human biology (with some exceptions). That’s very different from drug studies, where the molecules not only have to have the same effect in the model species, but also all off target effects have to be similar. That’s a higher barrier to clear and why mice studies of pharmaceutical interventions should (and do) face higher scrutiny.
Paper: https://www.cell.com/immunity/fulltext/S1074-7613(26)00440-1
Granzyme K is the protein.
Great, finally Leonardo DiCaprio will be able to find his life partner.
Paywall
Thank God! Finally, mice that don't age!
I’d unironically love to have a pet rat that lives longer than a few years.
Can't wait for this to escape in New York City. Ageless undying sewer rats - what a utopia haha.
In mice.
Humans have the same protein. Knock out studies in mice have historically been very informative about human biology (with some exceptions). That’s very different from drug studies, where the molecules not only have to have the same effect in the model species, but also all off target effects have to be similar. That’s a higher barrier to clear and why mice studies of pharmaceutical interventions should (and do) face higher scrutiny.